In Colombia, emergency services are characterized by the great congestion that occurs in institutions that provide this type of care to the community. The goal of this study was to perform a Prototype of IoT Technological Infrastructure for Monitoring Vital Signs in Patients in an Emergency Department. Methodologically, five stages were developed that consisted of characterizing the primary care process in the emergency department of a public institution, then the design of the prototype of technological infrastructure was carried out, followed by the construction of the prototype of technological infrastructure and finally the evaluation of the prototype of technological infrastructure. it is concluded that development of the project allowed to verify the feasibility of using current and innovative technologies such as IoT, in real environments, under conditions with scarce technological resources and with critical processes, such as those of a public health institution.