1548 Background: The management of women with BC includes GCRA for those at risk of carrying deleterious BRCA mutations. GCRA can aid decisions regarding RRS, including contralateral risk reducing mastectomy (CRRM) and risk reducing salpingoophorectomy (RRSO). The uptake of RRS among Hispanic women with BC is unknown, partly due to disparities in access to GCRA. We hypothesized that these disparities may be accentuated in Latin America (LA). Methods: Hispanic women from the US & LA (Mexico, Colombia, Peru & Puerto Rico) with history of BC who underwent GCRA, enrolled in the Clinical Cancer Genomics Community Research Network registry from 1997-2016 were included. Demographic characteristics and data regarding RRS were obtained from chart reviews and self-reported surveys. Data was analyzed using Fisher’s and x2 tests. An adjusted logistic regression model including a set of selected factors was used to predict the likelihood of undergoing RRS. Results: RRS data was collected on 1,517 Hispanic women with BC. 270 (17.7%) were BRCA carriers and 1247 (82%) non-BRCA carriers. Median age at GCRA was 44 years (y)(range 17-87). Median follow-up was 2.6 y. RRS were more common among BRCA carriers (34% CRRM and 27.7% RRSO) compared to non-BRCA carriers (18.6% CRRM and 4.1% RRSO). Of those that had CRRM, it occurred after GCRA for 79% of BRCA carriers and 50% of non-BRCA carriers. Factors associated with CRRM in BRCA carriers were: ≥1 pregnancies (OR 0.3, p 0.01), and living in the US (OR 5.2, p < 0.01). Factors associated with CRRM among non-carriers were: older age (OR 0.9, p < 0.01), ≥1 pregnancies (OR 1.4, p 0.4), family history of cancer (OR 1.9, p > 0.1), living in the US (OR 30.6, p < 0.01) and previous ipsilateral mastectomy (OR 2.9, p < 0.01). Conclusions: RRS uptake among Hispanic women with BC in LA was lower than previously reported in other populations. GCRA may influence risk appropriate RRS uptake, especially for BRCA carriers. CRRM and RRSO can prevent new primary cancers, and RRSO can improve survival for BRCA carriers, so a better understanding of behavioral factors is needed to inform interventions to improve risk appropriate uptake of RRS among Hispanics.