Background: Zika virus (ZIKV) infection has affected significantly affect Latin America in 2015-2016. However, most studies have been reported from Brazil and Colombia, but there is lack in Central America. We analyzed the incidence, incidence rates and evolution of cases at national, departments and municipalities of Honduras during 2016-2017, since the epidemics begun on January 2016. Methods & Materials: Observational study in which the incidence of ZIKV infection, in Honduras, 2016-217, was estimated, based on data from national epidemiological surveillance, obtaining the number of cases for each department and municipality, 2016-2017 (by epidemiological weeks, EW), from EW1-2016 to EW24-2017. Data used for this study are constituted from confirmed cases. Data proceed from 298 primary municipal notification units, collected at 18 departments, centralized in Tegucigalpa (Capital District, CD). Cases of Zika were clinically and laboratory confirmed (RT-PCR). Results: From January 1, 2016 to June 17, 2017, 32,405 of Zika were reported (cumulated rate: 368.5 cases/100,000pop). From them, 1% were RT-PCR confirmed. The highest peak was reach on the EW6-2016 (2,559 cases;29.34 cases/100,000 pop), followed them, after a decrease to 93 cases (1.07 cases/100,000 pop) (EW12-2016), of a second at EW24-2016 (988 cases;11.33 cases/100,000 pop). The department with the highest number of cases was Cortés (13,128 cases;2,832.9 cases/100,000 pop). Francisco Morazán department (which includes the CD) had the highest incidence rate (3,213.6 cases/100,000 pop;10,587 cases). From the total cases of Francisco Morazán, 99.25% occurred at the capital city, Tegucigalpa. So far, 4 cases of congenital Zika syndrome (CZS) have been confirmed. Conclusion: Pattern and evolution of Zika in Honduras has been like those that occurred for chikungunya in 2015, that we analyzed and published (JPHI 2016), affecting predominantly the central and capital area of the country, reaching also high incidences there > 2,000 cases/100,000pop. Studies using geographical information systems, to map its epidemiology, as well on the clinical aspects linked to, such as the CZS and the associated Guillain-Barre syndrome, are necessary in this country, given the extend of the epidemics and the associated consequences.