Epidural analgesia (EPA) is a recognized approach to pain control that is used in approximately 50% to 60% of all abdominal major surgeries around the world. It constitutes an important issue among strategies of multimodal postoperative analgesia, due to its potential to improve rehabilitation, low rate of complications, and high satisfaction reported by patients.1,2 Worldwide trends to use epidural catheters at high spinal levels (usually T6-T8) and new delivery systems that provide pain rescue modalities added to classic continuous infusions have the potential to reducing the rates of related adverse events (uncontrolled pain, motor block, and urinary retention).3 Besides recognized advantages of EPA based on moderate to strong evidence, there are detractors who warn on a potential increase of intestinal leakage, but available information is of low/doubt quality and recent related papers have not found any association.4,5 Hypotension remains as a big problem related to EPA and future research must focus on strategies to prevent it. Acute pain management services play a key role to implementation of standardized protocols of EPA in order to reduce postoperative morbidity and improve quality and safety (Fig. 1).Figure 1: Impact of epidural analgesia for major surgery on perioperative outcomes and recommended puncture levels for different procedures.Ethical disclosures Protection of human and animal subjects. The authors declare that no experiments were performed on humans or animals for this study. Right to privacy and informed consent. The authors declare that no patient data appear in this article. Funding Author's own resources. Conflicts of interest Authors declare no conflicts of interest implied in the writing of this manuscript.