Background: Long-term consequences of chikungunya (CHIK) and its chronic inflammatory rheumatism (pCHIK-CIR) are not fully understood yet and include and increasing number of non-rheumatological effects, among them, sleep disturbances and fatigue. Methods & Materials: In a cohort study among 62 cases serologically diagnosed in La Virginia, Risaralda, Colombia, followed-up by 2-years, demographic and clinical characteristics were collected at baseline. Pittsburgh Sleep Quality Index (PSQI) (used with written permission) and Fatigue Severity Scale (FSS), validated in Spanish and for Colombia (Cronbach α=0.78 and 0.88, respectively), were applied to patients with pCHIK-CIR (+) and without (-), all under follow-up at 2 years. Score comparisons (Wilcoxon signed-rank test) and prevalence proportion (χ2) significances were calculated using Stata IC 14.0® licensed, p significant < 0.05. Results: We compared 43 patients with persistent rheumatological symptoms (pCHIK-CIR + ) and 19 without it (pCHIK-CIR-), all them followed-up for 2 years. Mean age was 44.1 y-old, 69% female. At the PSQI we found significant differences in the wake-up time (item-3), pCHIK-CIR + do early (median 5:00am versus 6:00am in those pCHIK-CIR-) (z = 2.699; p = 0.0069), sleep less time (item-4) (mean 6.46 hours vs 7.79) (z = 2.51; p = 0.0121), they have more somnolence from < 1 times/week to ≥3 times/week (item-8) (46.5% vs 10.5%) (χ2 = 7.454; p = 0.006), have somewhat to very big problem keep up enough enthusiasm to get things done (item-9) (46.5% vs 10.5%) (χ2 = 7.454; p = 0.006). FSS were significantly higher in those with pCHIK-CIR + , 55.2 vs 37.5 (z = 2.303; p = 0.0213). Conclusion: Sleep is significantly impaired among pCHIK-CIR + patients as well they also presented with more fatigue, compared to those that recovered during acute phase of disease. This is the first study in screen these aspects with validated questionnaires, raising the relevance of such assessments in patients with acute but also chronic chikungunya consequences. Findings have significant implications in areas affected by chikungunya epidemics, as well later endemic areas with chronic disease.