During potato’s harvest, a relatively high volume of leaves (residues) is generated per hectare. According to the literature, these leaves may contain secondary metabolites such as solanesol, a substance of high added value and wide applicability in pharmaceutical and cosmetic industries. The present contribution describes the extraction of solanesol from potato leaves harvested in Antioquia by means of organic solvents, and the use of indirect iodometric titration for solanesol quantification, corresponding to a relative inexpensive and easy implementation technique. Yields between 0.23 and 0.32% wt/wt of solanesol relative to the dry material were obtained. This resultas ares comparable with other techniques (i.e., microwave assisted extraction) and other raw materials (i.e., tobacco leaves), commonly used to obtain the metabolite. The present research constitutes a contribution for the extraction and characterization of the solanesol for marketing purposes).