In order to generate a strategy for managing the cultivation of cocoa in the sub-regions of the department of Antioquia (Uraba and Northeast), it was selected for each of the class 20 and 23 farms respectively. In each farm 14 chemical variables were evaluated, with major and minor elements, and three physical variables (sand, silt and clay). These variables are used to evaluate the fertility of the soil and the agreement with the state of each of them generates a general comprehensive management proposal. We found the soils of the Northeast sub-region are not very fertile with respect to the soils of Uraba, as well as the soils of the Northeast that have low capacity of effective cation exchange, bases, high interchangeable acidity and iron content. In the case of the minor elements, the soils of the sub-region of Uraba represent a balance at the medium level, while in the Northeast, their contents are located at different levels, according to literature reports. In terms of agronomic management, it is advisable to apply lime to the soils of the Northeast due to the high saturation of aluminum. In addition, given the low content of interchangeable bases, it is necessary to apply sources with calcium and magnesium available for plant nutrition, while in Uraba soil is presented as a reserve of these elements.