Cities have increasingly been confronted with disasters, ranging from earthquakes and storms to floods and landslides. Traditional technocratic top-down approaches have proved inadequate to face disaster risks in urban agglomerations. Thus, expectations have risen that through multi-level governance, metropolitan regions could become more resilient by joining forces across scales and sectors, enabling them to implement adaptation strategies collectively. Under the leadership of the city of Medellin and integrated within the national risk governance system of Colombia, such a governance arrangement has been established in the Metropolitan Area of the Aburra Valley. Applying social network analysis, this paper analyses the institutional relationships within the multi-level risk governance network Red Riesgos. It demonstrates that the effectiveness of multi-level disaster risk governance networks depends primarily on the protagonist role of local governments and on their abilities to involve local communities and citizens and to interact constantly with higher-level authorities in the implementation process.