Summary: The purpose ofthis article is to present a review of different investigation approaches to evaluate thebiocompatibility of dental materials. A search was conducted among the investigators in this fieldin order to define the test methods applied to evaluate dental materials. The described stages foreach test are found in the literature used to evaluate the biocompatibility of different materialsused in dental practice. At the end of this review it can be concluded that compliance with researchprotocols and results obtained on biocompatibility of these studies provide confidence for the useof various dental materials. Key words: Dental materials. Biocompatiblity. Citotoxicity. Dentalpulp.