Malaria is a human vector-borne disease that causes an enormous burden for communities worldwide. Plasmodium vivax and Plasmodium falciparum are protozoan parasites responsible for most of the, approximately, 219 million clinical malaria cases and 660,000 deaths reported annually. Effective vaccines could significantly contribute to strengthening malaria control programs and accelerate the progress toward malaria elimination; therefore, representing a medical priority for global health. However, Plasmodium parasites have an inherently complex lifecycle that renders this vaccine goal a phenomenal technical challenge.