In this work, it is a journey that begins with some background linked to the Uni-ted Nations Organization for Education, Science and Culture (UNESCO) as its educational proposals gave a strong im-petus to the theme of coexistence, with a focus universal, inclusive and forward-looking. Secondly, the process carried out in an investigation carried out in Mexico (Perales, Arias & Bazdresch, 2014) is addressed and it gives the gui-de to visualize cross-cutting coexisten-ce factors that take place in the human interactions of the school environment, which derive in the which is named as socio-affective nuclei. This new perspec-tive allows us to enter not only into the exteriority of human activity, but also into a reflection on the connection with the corporeity of the human being in ge-neral. Finally, two themes are proposed that can guide the actions of this new vi-sion: One is the ethics of care versus the ethics of responsibility; and the other, that of “provention” versus “prevention”, which invite us to go beyond a strictly programmatic stance like that which is usually established in schools.