Hybrid lesions of the oral cavity are infrequent and share characteristics with a number of other pathologies. Both odontomas and dentigerous cysts are of odontogenic origin, but their simultaneous occurrence is rare and scarce. Clinical and radiographic examinations are not conclusive, making their identification difficult, while histopathological studies can reveal their defining characteristics. The aim of this report was to describe the radiographic and histomorphological findings of a hybrid lesion formed by a complex odontoma and a dentigerous cyst, affecting the mandible of a 22-year-old man, from Cartagena, Colombia, who had no relevant medical history, and no symptoms or discomfort in the affected area.