Obtaining bubbles on demand at precise times and locations in a non-contact fashion can be useful in a variety of applications. Of special importance is the combination of laser nucleation with acoustics, so that bubbles are only just nucleated by the optics but grown to macroscopic size solely by the acoustics. We present theory and experiment for the non-thermal laser nucleation of bubbles in an acoustic field in the absence of significant absorbing/scattering particles. First we present theory and experiment for the threshold for dielectric breakdown in water, resolving the distinct minimum at 20 bar. Then, we present a method and results for nucleating single and multiple bubbles with temporal uncertainty of 5 ns, and spatial uncertainty of 1 mm. Results for bubble number and first cycle expansion are reported as functions of the timing of the nucleating laser pulse with respect to the acoustic field. [Work supported by Impulse Devices, Inc.]