Introduction: a systematic review of the literature about randomized controlled trials in patients with overlap phenotype, which were included in pulmonary rehabilitation, is presented.Materials and methods: a systematic search in nine databases, which included one about specific topics in physiotherapy, were done. Studies were filtered by title and abstract after applying inclusion criteria. Selected studies were analyzed using the CONSORT, Jadad and PEDro scales.Results: 38 results were filtrated after the systematic search. A total of 12 studies approved at least 2 of 3 scales, being characterized as good or excellent. Reviewed studies evidenced heterogeneity in the methodological design and interventions presenting failures in randomization and blinding.Discussion: no studies were found in the initial search with the mesh terms overlap phenotype and COPD. After the implementation of a subgroup analysis, was evidenced heterogeneity in the publications that centered in pulmonary rehabilitation and COPD. During the search, no Colombian high impact publications where found.Conclusion: according to the found data, it is concluded that the interventions with higher impact in the pulmonary rehabilitation process in patients with asthma and COPD are unknown, the subgroup analysis evidenced improve in functionality in patients with COPD after the implementation of domiciliary therapy and Chinese traditional medicine. Nevertheless, according to the heterogeneity of the data, those results should be verified with new studies that develop in an integral way the topic.