Multiphase flow is a well-known studied subject, due to its importance in many industrial processes that affects human kind.This type of flow is found in the upstream of the oil industry and the most frequent pattern is slug flow.This pattern has the characteristic of being an intermittent flow nature that has a sequence of elongated bubbles followed by portions of liquids.Slug flow hydrodynamics is complex and of great importance to be modelled.Many researches have been studying two-phase flow air/water (Newtonian fluid) but in certain occasions the two-phase flow encountered in the industry has the behaviour of non-Newtonian fluids.The objective of this research is the validation of a CFD model with the experimental data obtained in the University of Brescia that represents a two-phase air/non-Newtonian slug flow.The CFD model was implemented with an orthogonal mesh and specific physics that represent the studied system.One of the most significant model is the power-law that describes the behaviour of the non-Newtonian fluid used in this study: CarboxyMethyl Cellulose CMC-water solutions.Three different concentrations of CMC were used (1, 3 and 6% w/w).The parameters evaluated were: slug frequency, dimensionless slug length and pressure drop.The relative error for the first two parameters was 24.22% and for the pressure drop 45.10%.The overall relative error obtained was of 34.66%.With this results the model is representing the experimental data but it can be improved by slightly changing the used boundary conditions and implementing additional models that can describe in a better way the interface between the two fluids.