Cancer is the leading cause of mortality in the worldwide, with around 8.8 million deaths in 2015 in accordance with World of Health organization (WHO). 1 For this reason, this disease has a particular research interest in order to reduce the prevalence and mortality rates.Biomarkers in cancer provide a powerful approach to understand this complex disease as well as giving the possibility of timely diagnosis in a noninvasive way and it has different applications in epidemiology, diagnosis, progression and prognosis.At the other side, the Biosensors are instrument employing biological recognition properties for a selective bio-analysis and converts the molecular recognition signal to an electrical signal.Both technologies can support each one; biosensors can discover new biomarkers and biomarkers that drive the construction of new biosensors.This opinion will briefly summarize the "pros and cons" of this technologies to cancer detection, follow up and prognosis.