This research proposes a methodological guide to design a proposal for the creation of a project management office (PMO) at the University of Cartagena.As a methodology, a conceptual model consisting of the following phases is proposed: Diagnosis, Selection of the population and study sample, Design and application of surveys, Analysis of information collected and Proposal of PMO.For the case study, and in order to validate the effectiveness of the proposed guide, the previous items were implemented at the University of Cartagena.For the analysis, the variables were identified: Maturity in Project Management, Methodology Level in Project Management, Project Management Tools, Competency Development Level in Project Management, Methodology Level in Portfolio Management, Methodology Level in Direction of Programs and Multi-Projects, Level of Office of Project Management; these were classified between medium and low levels of development.In response to the above, it is stated that the type of PMO according to the structure of the University is "Control Tower".The conclusions indicated that the guide allows: creating PMO proposals, finding strengths, weaknesses and establishing PMO functions in organizations.Keyword -PMO,