The present study aimed to evaluate the psychometric properties of the multidimensional scale of perceived social support (MSPSS) in Colombian adolescents. We conduct a cross-sectional study and recruit 766 adolescents from 14 to 18 years old. The internal consistency of the scale was d and model fit from confirmatory factor analysis (CFA). The internal consistency of the scale was .84 (95% CI = 0.83-0.86), with small to negligible changes when specific items were ped. Construct validity was confirmed by the goodness of fit of a Three-Factor Model and correlation between items 3-4, 1-2, 6-7, and 5-6, AGFI = 31,680.98, BIC = 31,824.74, NNFI = .946, CFI = .975, and RMSEA = .049, confirming the model structure proposed by Zimet and colleagues. The findings demonstrate that the MSPSS is a suitable instrument to evaluate perceived social support in Colombian adolescents.