In this work, the phenomenological based semi-physical model (PBSM) approach to build up a model for glucose homeostasis in the human body is discussed. Regarding the big picture, a physiological model of the gastrointestinal (GI) tract is envisioned without assuming low energy consumption as it is used in available representations. The focus is on particularities of PBSM, specially on the use of analogies from known processes to represent complex biological phenomena, mainly when uncertainty about the real process behaviour and operation is high. In spite of the latter assumptions, the PBSM approach allows proposing a reliable description of the glucose homeostasis with interpretable parameters. In this regard, the main challenge and hence the main step of the approach is to find out an analogy from process engineering for every organ involved in the homeostasis. Therefore, known mathematical representations arise. Following the ideas above, this work discusses reliable analogies for stomach, small intestine, kidneys, liver, and pancreas. A simulation result, showing the success of the approach, is presented for stomach glucose consumption during a typical meal. Future works are enumerated in the frame of the major research project being developed among one hospital and two universities in Colombia.