<b>Background:</b> Poor adherence to inhaled therapies is common in COPD patients and associated with poor outcomes. Patient self-report methods to asses adherence are the most used in clinical practice. Limited information exists regarding the agreement between different methods. <b>Objective:</b> To determine the adherence to inhaled therapies in COPD patients and the agreement between two self-reporting adherence questionnaires. <b>Methods:</b> A total of 795 COPD patients (FEV1/FVC<0.70 post-bronchodilator) participated in an observational, cross-sectional multinational, multicenter study. Adherence to inhaled therapy was assessed with the Test of Adherence to Inhalers (TAI) and the Morisky-Green (MMAS-8) questionnaires. The Kappa (κ) index and percentage of agreement were used in the analysis. <b>Results:</b> Patients had mean age of 69.5±8.7y. and FEV1% post-bronchodilator (BD) 50.0±18.6%. 97% of patients used any respiratory medication, 91% any BD and 53% any combination of BD + inhaled corticosteroid. According the TAI questionnaire 54.3% of the patients had good, 26.6% intermediate and 19.2% poor adherence. By the MMAS-8, 51% had high, 29.2% medium, and 19.8% low adherence. Agreement between TAI and MMAS-8 questionnaires was low-moderate: κ index= 0.42; % agreement = 64.7% (see table below) <b>Conclusion:</b> Around 50% of COPD patients had good adherence to inhaled therapies according to both questionnaire and 20% low. The agreement between the questionnaires is low-moderate. Adherence to inhaled treatment is crucial to optimize clinical outcomes in COPD; greater efforts should be made to improve adherence.
