<b>Background:</b> Respiratory symptoms have an impact on quality of life of patients with COPD. <b>Objective:</b> To investigate the frequency of respiratory symptoms along the 24 hour day, their intensity and related factors in a COPD population from 7 Latin American countries. <b>Methods:</b> Information was available from 734 COPD patients participating in an observational, cross-sectional multinational, multicenter study. Symptoms were evaluated with the Evaluating Respiratory Symptoms in COPD (E-RS) questionnaire, the Nighttime Symptoms of COPD Instrument (NiSCI) and the Early Morning Symptoms of COPD Instrument (EMSCI). Pearson coefficient was used to estimate the correlations between the daytime symptoms (E-RS) and CAT score, FEV1 and night and early morning symptoms severity score. <b>Results:</b> Among participating patients, 61% were male, with mean age of 69.6±8.7 years, mean FEV1% post-bronchodilator 49.7±18.6% and CAT score 13.2±7. The mean score for E-RS was 10±7, NiSCI 2.3±3.7 and EMSCI 3.3±3.6. Up to 20% presented significant morning and 18% nighttime symptoms in last day. Cough was the most frequent symptom during the day, in the morning and at night. Intensity of symptoms during the day (E-RS) correlated with CAT score (r=0.715, p&lt;0.001), morning symptoms (r=0.739, p&lt;0.001), nighttime symptoms (r=0.644, p&lt;0.001), and weakly with FEV1(%) (r=-0.192, p&lt;0.001). <b>Conclusion:</b> Patients with COPD are highly symptomatic. The observed frequency of morning and nighttime symptoms is lower than previously described because we investigated only the symptoms in the previous day. Intensity of symptoms during the day significantly correlates with the CAT scores, symptoms intensity in the morning and night but poorly with lung function impairment.