Introduction: Colombia is known worldwide for its high rates of violence as the result of the narcotics war and the presence of political-rebel groups; guerrillas. The violence increased dramatically during the 1990s and early 2000s, which is when it achieved its greatest influence. Nowadays the situation has changed. The Colombian government has retaken control, acting to decrease the macro and micro narco-traffic and a peace process with the guerrillas is ongoing. Because of this, Colombia is undergoing a social transition and the rate of all types of violence has decreased substantially. Aim: To investigate and report the direct impact of the decreased rates of violence on organ procurement and transplantation in Colombia. Materials and Methods: A 10-year retrospective study of national and international data reports on interpersonal violence, intentional homicide and car accidents including the data of The National Institute of Coroners and Forensic Science of Colombia. Results: The homicide rate in Colombia has decreased from 67.5 per 100,000 inhabitants in 2002 to 33 per 100,000 inhabitants in 2012; 91% of murders occurred in males aged 20 to 35 years in the last decade. The primary homicide trigger was the guerrillas war in 2002 and now seems to be the interpersonal fights in 2012. Although shooting has declined substantially from >24,000 in 2002 to <12,000 in 2012, it remains the most common mechanism of death (75%). On the other hand, the rate of deaths due to car accident has also decreased. Regarding organ procurement, the number of effective brain-death donors has decreased substantially. Also, the main cause of brain death changed from trauma in 2002 to stroke in 2012. Conclusions: It is quite interesting to see how the social transition and the peace process that Colombia is undergoing directly impacts on the health system including the Colombian Network of Organ Procurement and Transplantation (CNOPT). There is a reduction in all types of violence; brain-death donors due to gunshot wounds and traffic accidents are less now than 10 years ago. Thus, the transplants performed using living and extended-criteria donors are now fundamental. Designing new strategies has been necessary to adjust the CNOPT to a modern society, in order to increase the amount of effective donors. Those strategies may be an archetype to the countries that are living in a social transition like Colombia.