The purpose of the study is to generate a discussion on the Ethical-Legal Equity of Science for the Emancipation of Knowledge and Knowledge, based on the reflective investigation of the ethical-legal principles that underpin the National Constitution of countries such as Chile, Peru, Ecuador, Colombia and Venezuela the significance of science built from the contextual foundations of knowledge, knowledge and common sense originating in South America. Reflective inquiry is oriented from juridical sociology, to approach from the contrasting and systematization of the constitutional articles, that make visible the emancipation of the integrated knowledge to the original knowledge in the mentioned countries. The article is an advance of the research project titled “Contextualization of emancipatory knowledge, from the local”, that the authors advance in the Line of Research Ethos and cultures in the Organization (UNERMB-CDHCT). The final consideration is that equity in ethical and juridical principles in the National Constitutions of Chile, Peru, Ecuador, Colombia and Venezuela to integrate knowledge and common-sense knowledge, from a science built by and for South America.