Background: Lower lip squamous cell carcinoma (LLSCC) is a common malignancy of the head and neck, being mainly a consequence of a chronic exposure to ultraviolet (UV) light solar radiation.Here, we evaluated the clinicopathological profile of patients with photosensitive disorders (xeroderma pigmentosum, lupus erythematosus and albinism) that developed LLSCC.Material and Methods: Data from patients who had a diagnosed LLSCC with a prior xeroderma pigmentosum, lupus erythematosus or albinism diagnosis that were treated at INCA from 1999 to 2012 were collected from patients' medical records (n=16).The control group was composed of 68 patients with LLSCC without a medical history of photosensitivity.The clinicopathological data of this study population were collected and the association between these variables was analyzed by Fisher's exact test.Survival curves were constructed using the Kaplan-Meier method and compared by log-rank test.All statistical analyses were performed using SPSS statistics package.Results: The mean age of patients in the photosensitive and non-photosensitive groups was 42 years and 67 years, respectively (p<0.0001).A previous history of malignant diseases was more common in the photosensitive group