This paper seeks to highlight the central role of American in the European imperial expansion in the early globalization from the sixteenth century. It does it by using cannabis sativa, key input in the rigging of vessels which consolidated the oceanic routes as an example to discuss their artificial migration to the American biota. Right after, we propose a hypothesis of relationship between the difficulties of the Baltic cannabic trade flow, and the increasing encouragement measures cannabic grow in American lands. Finally, we briefly develop the role of hemp farming in Chile and its sale in its traditional markets in the Mar del Sur ships and the Peruvian Viceroyalty.