Objective: To evaluate and compare the relationship between Lipid Accumulation Product (LAP) and Visceral Adiposity index (VAI) with the components of the metabolic syndrome (MetS) in Venezuelan adults.Methods: Cross-sectional, observational analytical study, comprising 332 individuals selected at the Endocrine Service of the Hospital Militar "Dr Carlos Arvelo".Anthropometry (BMI, WC) and fasting biochemical parameters (TG, HDLcholesterol) were measured and the LAP and VAI (fats indexes) were estimated.Patients were classified into 3 groups with and without Metabolic Syndrome following the ATPIII criteria and a group with Cardiovascular Disease (CVD).Results: 73.17% of the individuals were female and 26.82% were male, with 123 (37.04%) individuals without Metabolic Syndrome (non-MetS), 137 (41.27%) with Metabolic Syndrome and 72 (21.68%) with CVD.In the group without Metabolic Syndrome, we found: LAP (6.72 -26.28) and VAI (0.71 -1.85), for the group with Metabolic Syndrome: LAP (42.09 -108.57) and , with significant differences between groups (p <0.005) and in the CVD group and .Discussion: the results obtained agreed with studies carried out in different populations and ethnic groups (Asia, Middle East and Latin America), indicating that the LAP index obtained better precision for MetS screening, regardless of gender and BMI, the VAI index was best predictor of Cardiovascular Disease.