This paper describes a new self-adaptive hardware architecture with fault tolerance capabilities and a development system that allows the creation of applications. This bioinspired architecture is based on an array of cells with capacity for parallel processing, which implements in a distributed way self-adaptive capabilities, like self-routing, self-placement and runtime self-configuration. This cell array together with a component-level routing constitutes a SANE (Self-Adaptive Networked Entity). An integrated development environment and a physical prototype based on two FPGA boards has been built in order to assess the features of the proposed architecture.