The last decades have brought different changes in the cosmovision and forms in people ́s life characterized by a speed, depth and intensity never seen in any other historical moment. It could be mentioned globalization, the emergency of neoliberal economy, the appearance of gigantic multinationals and the relativization of the States as guarantors of the world order. Linked to the appearance of the computers and the Web World Wide, it has emerged new ways of using the language, knowledge, and the relationships; all of them are facts that have transformed the ways of conceiving and being in a world, confronting the establishment. The school, the family, the work, the religious and scientific institutions, are facing among them this "new age ", forcing the subjects, until a few decades ago orientated by adaptive logic, in pursuit of progress, and being assumed as natural monads, individual and intrapsychic (subjects/structure), that have to do with the relativization of universal laws, the change and the uncertainty (proteiform subjects). The previous things have questioned the clinical psychology, claiming for deep transformations in the conditions of the attention, the adequacy to the social security systems, the response to new problematic and the review of the ontological, gnoseological and anthropological suppositions, which have been used for long as a support. Finally, it is proposed a review of the requirements, tensions and challenges for the clinical psychology derived from the transition of the structured subject to the proteiform subject in the contemporaneity as a contribution to the analysis of the response that this discipline can provide to the deep transformations arisen in the last decades.