The icthyotoxic, cytotoxic and antimicrobial activities of aqueous, ethanol and chloroform extracts of 11 sponges from the Santa Marta region, Colombian Caribbean, were assayed. All studied sponges showed antimicrobial activity; 6 were ichthyotoxic and 7 were cytotoxic. Ircinia campana, Verongula rígida, Agelas conifera and Didiscus oxeata, were found to have activity in all three kinds of tests.