Ependymomas are neoplasms of the central nervous system (CNS) that are classified in grades I to III.They represent 10% among CNS neoplasms and increase up to 30% in the population under 3 years.The origin is postulated in the cells of the radial glia.Pathology studies, biomolecular and genetic tests have established biological differences between ependymomas according to anatomical location, risk groups have been classified that associate molecular genetic information with epidemiological variables and have facilitated a better stratification of patients.Treatment is surgery with complementary radiotherapy.The purpose of this article is to present three cases of anaplastic ependymomas (AE) that are relevant due to the low frequency of presentation among CNS tumors, to review the genetic and biomolecular markers that grouped with clinical epidemiological variables are impacting the therapeutic schemes.