<h3>Background</h3> Rheumatic diseases are the leading cause of permanent disability. In our country are the fourth cause of consultation in health institutions. The COPCORD model constitutes an effective tool in the determination of the prevalence of diseases. Globally, this model has been carried out in Asia, Europe and in some countries of Latin America. In Colombia the epidemiology of rheumatic diseases is not known globally; this would be the first national study that uses the data collection questionnaire using the COPCORD instrument <h3>Objectives</h3> To estimate the prevalence of rheumatic disease and related factors in a Colombian population over 18 years of age in six Colombian cities <h3>Methods</h3> A Cross-sectional analytical study was designed in people older than 18 years. A probabilistic stratified sampling method using three stages. The first stage of sampling was the selection of cartographic sectors in each city. The second stage of sampling was the blocks of each sector. The third stage of sampling was the homes of each block. All household members were surveyed. The sample size was calculated to be 6,528 people (2336 from Bogotá, 1220 from Medellín and Cali each, 746 from Barranquilla, 503 from Bucaramanga and Cúcuta each). The COPCORD questionnaire adapted for Colombia, was applied in the first stage by standardized interviewers. Positive cases were reviewed at home by a first year rheumatology fellow. To assess whether it is a rheumatic disease; the positive cases for a probable rheumatic disease were reviewed by a second year rheumatology fellow and reviewed again with laboratory and image studies by a certified rheumatologist to establish the definitive diagnosis <h3>Results</h3> 3,146 men and 3,547 women were included. Pain in the last 7 days not associated with trauma was reported in 3,213 (48%) participants. The most frequent sites were knees (right 31%, left 29%), hands (right 25%, left 24%), lumbar spine (18%) and shoulders (right 16%, left 14%). Table 1 depicts the prevalence of rheumatic diseases in Colombia <h3>Conclusions</h3> Our study shows a similar prevalence to those worldwide in scleroderma, dermatomyositis, systemic lupus erythematosus, and spondyloarthritis. A lower prevalence was observed in Sjögren Syndrome, fibromyalgia, gout and osteoarthritis. A slightly higher prevalence of rheumatoid arthritis was observed in our population. The high prevalence of rheumatoid arthritis and soft tissue rheumatism should increase awareness in our governmental health entities given their long term disability risk <h3>Disclosure of Interest</h3> None declared