Increasing data has shown the relationship between Zika Virus (ZIKV) and neurological complications. However, there are still uncertainties about the prognosis of these complications. The aim of this study is to show the neurological characteristics of patients six months after a Guillain–Barré episode related to ZIV infection. Patients with a Guillain–Barré episode were identified prospectively at five intensive care units in an endemic zone in Colombia (Valledupar, near the Caribbean coast of Colombia). Brighton´s criteria for Guillain–Barré case definition were used to classify the patients. Clinical data from the clinical records was used. Patients with a positive Zika serology were followed after 6 months. Of 25 patients with a diagnosis of Guillain–Barré, 20 had a serological study for ZIKV and it was positive in 19 patients (95%). Seventy-five percent of the cases were men, the median age was 45 years old and they had a median length of stay of 25 days. 68% had a febrile syndrome in the 7–14 days prior to hospitalization. Median time between fever and neurological symptoms was 9 days. Incapacity to walk was found in 100%, dysphagia in 55%, and respiratory insufficiency in 55%. Patients were treated with immunoglobulin or plasmapheresis. Median time to follow-up was 193 days in 15 patients. Cuadriparesia was found in 44%, difficulty to walk in 31%, unilateral facial palsy in 19%, and bilateral in 6%. Dysphagia or respiratory distress was not found. Eighty-seven percent of the patients were independent for basic and daily activities. Guillain– Barré syndrome related to ZKV infection is a severe disease with a high grade of disabilty at 6 months after the episode. All authors: No reported disclosures.