This paper is the result of a quantitative research study, which identified structural gaps for the incorporation of Social Responsibility in small and medium-sized enterprises in the textile sector in the south-central region of Caldas. Research was conducted by means of interviews using methodological tools defined by the ISO 26000 international guidance standard and ISO 9001, ISO 14001 and OHSAS 18001 standards. The results allow to highlight weaknesses in the strategic platform and implementation of quality management, environmental and occupational, safety and health systems. Structural gaps in the core subjects of social responsibility, in communication strategies, and in the actions for social responsibility integration throughout the organization were identified.