Royalties are income from rights given to the state for the extraction of non-renewable natural resources. In order to guarantee the equal distribution of these funds, Colombia created the General System of Royalties, which allocates 10% of these investments toward science, technology, and innovation programs considered a priority by each region. Carrying out royalty programs is complex due to the fact that each development phase requires that multiple actors be in agreement, including regional and city administrative offices, the academic sector, the private sector, the communities where the programs will be conducted, and the project evaluation and supervision entities, namely the National Planning Department and Colciencias as technical secretariat. Within this complex framework, we present the experience of EAFIT University in the design of a Project Management Office (PMO) model and the partial results of the implementation of two programs funded with royalties, which evidenced the need to structure a management model to coordinate programs requiring a higher level of follow-up and supervision, thus ensuring a responsible management of public resources under the private sector scheme where efficient and articulated communication channels were established amongst those interested and in accordance with their requirements. This model was adjusted based on the areas of knowledge and process groups proposed by the PMI.