Background: Road traffic injuries and fatalities have increased in Colombia despite that 2011-2020 had been declared as the Decade of Action for Road Safety in the world.Then, this paper aims to describe the trends of motorcycle mortality patterns in Colombia from 2000-2013.Methods: A longitudinal study is carried out using mortality records from the Colombian National Department of Statistics, and following the International Classification of Diseases -ICD-10 V200 to V299. Results:From 2000 to 2013 the study founded a near 100% increase in the number of motorcycle fatalities in Colombia; the occurrence rate increased from 3.6 to 5.7 per 100,000 populations.65.4% of the fatalities involve individuals from 15 to 34 years of age. Conclusions:Motorcycle fatalities have become a serious public health issue in Colombia.For the 14-year of the study period, slightly more than 28,800 motorcyclist's deaths have been attributed to different factors and social determinants.