In response to the demands of today's society, the teaching must overcome the fragmenting view of reality, developing educational and contextualized actions, in a way that the construction of knowledge can be established from the integration and articulation between the different knowledge by deploying complex thinking in science teaching.Faced with the challenge of developing this thought, interdisciplinary idea has been gaining strength in teaching and learning practices.However, in order to experience an interdisciplinary practice, we still found many challenges to be overcome in the Brazilian educational system.In this sense, the present study aimed to develop a proposal together with the teachers of a public high school, addressing the theme alcohol in its complexity.During the process, meetings were performed at the times of Collective Pedagogical Work Class for the construction of a theoretical reference, and after discussing times for preparation of the proposal, covering different disciplines of the State of São Paulo official curriculum for high school.The final product, which is an interdisciplinary proposal, can inspire other institutions attending to requests that are made to the school in relation to the formation process of critical and participative citizens, wich are able to contribute and intervene in society making decisions to socially responsible actions.