Objective: This study aims to determine the safety and efficiency of the combination in fixed doses of olmesartan and amlodipine 20/5 mg, 40/5 mg and 40/10 mg, in hypertensive patients treated in daily clinical practice for Colombian doctors.Design and method: This was an observational, prospective, open-label, multicenter, non comparative study. The primary outcome was changed in systolic blood pressure and diastolic blood pressure from baseline to week 12, and the secondary outcome was the proportion of patients achieving target blood pressure <140/90 mmHg. Moreover, safety and tolerability were also evaluated. The data was processed by analysis of paired observations, paired Student t-test, McNemar test for categorical data analysis and the repeated-measures analysis of covariance (ANCOVA). Two- tailed p- values of less than 0.05 were considered to be statistically significant. Statistical analyses were conducted by using STATA 12 (StataCorp). Results: A total of 428 patients were enrolled from 16 centers in Colombia. At 12 weeks the systolic blood pressure decreased in all three doses: by 27.75 +/− 20,73 mmHg in 20/5 mg, 31.13 +/− 22,23 mmHg in 40/5 mg and 46.96 +/− 20,15 mmHg in 40/10 mg (all p < 0.001). Furthermore, the diastolic blood pressure decreased by 14.19 +/− 12.89 mmHg in 20/5 mg, 16.25 +/− 10,87 mmHg in 40 / 5 mg and 24.83 +/− 10,41 mmHg in 40/10 mg (all p < 0.001). The percentage of patients achieving target blood pressure was 71.31% in 20/5 mg, 70.16% in 40/5 mg and 63.33% in 40/10 mg. There was no report of discontinuation of treatment with the use of olmesartan and amlodipine for 12 weeks. The proportions of adverse effects were headache 4 patients (0, 9%), dizziness 5 patients (1, 17%) and peripheral edema 3 patients (0, 7%). Conclusions: In this study of daily clinical practice in Colombian patients, the combination in fixed doses of olmesartan/amlodipine provides excellent systolic and diastolic blood pressure control, more than 63% of patients achieve blood pressure goals, reduce pulse pressure of 13 mmHg and it is well tolerated.