Introduction: Genetic variability related to the host immune system has been proposed as one of the most influential factors in the development of diseases caused by HPV.Clinical case: We report the case of a 5-year-old child in whom chronic laryngeal papillomatosis, probably acquired vertically during labor, was detected.The diagnosis of laryngeal papillomatosis was confirmed with a biopsy after a first surgery to remove the papillomas.The Derkay classification system was used to assess the severity of papillomatosis.Biopsy genotyping was performed by demonstrating HPV-6.Later, HLAD-QA1*0505, -DQB1*0301, -DRB1*1101 alleles were homozygous for HLA allele typing.Conclusions: Further studies are needed to identify the most prevalent HLA alleles in the Latino population and their potential association with genetic susceptibility in Recurrent Respiratory Papillomatosis.