Recent studies have reported cases of late-onset frontotemporal dementia (LO-FTD), a relatively rare disease since clinical symptoms of FTD have mainly an Early Onset (EO). The aim of this study is to illustrate the complexity of the diagnostic process investigating LO-FTD as well as the main considerations of aging effects of different variants: 2 cases with behavioral FTD (bvFTD) and two additional ones with non-fluent aphasia (PNFA) from a Colombian cohort of 100 FTD patients, will be presented. It seems that, for instance, LO-FTD was more common than previously thought and age onset of these 4 cases ranges from 80 to 92 years old. All 4 patients did not have Alzheimer’s disease neither vascular factors that followed an atypical course according to a clinical consensus diagnostic experts or MRI study, among others. Conclusion: Our study suggested that FTD is heterogeneous with respect the age of symptom onset. After controlling for the effects of chronological aging, EO-FTD a qualitative analysis suggests a great risk of misdiagnosis since even though they are similar to an atypical Alzheimer profiles (frontal variant of Alzheimer disease) clinical features are clearly different from other type of dementia.