A leader enables the transformation of individual capacities, converting them organizational strengths to put them at the service of the organization and thereby allow its sustainability and durability. The University in the XXI Century faces great challenges to continue contributing to the development of society, based on the fulfillment of its missionary functions: Research, teaching and extension. Transformational Leadership stands out as one of the best tools for university management to allow the organizational transformation that leads to solve problems such as financing, quality in education, increased coverage, and relationships with society, among others. This work, through a quantitative, rational positivist study, aimed to demonstrate theoretically the importance of Transformational Leadership in university management to face change and university transformation; And on the other hand, through a case analysis, characterize the Transformational Leadership present in the University, from the perception of the followers. For this purpose, theories of transformational leadership and management of higher education institutions, expert judgment, and the application of the Leadership Practices Inventory form of Kouzes and Posner -IPL- were used. Among the main results, the guiding hypotheses were validated, confirming the need to use Transformational Leadership in the process of the university management.