This paper presents an empirical research into the influence of individual characteristics of students and professors in the effectiveness of case method. We conducted 2 studies to test this influence. Study 1 used a quasi-experimental design to test the effectiveness of case method in a group of Colombian business students (n = 107) and the influence of students’ personality and motivation on learning outcomes (declarative knowledge and situation analysis) and satisfaction. Study 2 used a correlational design to test the influence of personality and attitudes of professors (n = 21) on students’ perceptions of case-method effectiveness (n = 442). Results from both studies indicated that case method is as effective as the lecture method on learning outcomes and is related with higher satisfaction on students. We also found that some personality traits (consciousness, openness to experience, and openness to culture) are related with learning outcomes and that mastery motivation has an important role on the perception of case method effectiveness. Finally, we found an interaction between professor and teaching methodology. Overall, our results suggest that the relation between case-method and learning and satisfaction is affected by personality and motivation.