ABSTRACT Objective: this study's aim was to estimate the content validity of nursing outcomes in relation to family caregivers. Method: eleven Brazilian and Colombian experts participated in the study. None of the 61 indicators of the four nursing outcomes were considered irrelevant; 42 (68.9%) were considered primary and 19 (31.1%) were considered secondary. Results: the indicators with higher validity scores were: family share care responsibilities for Caregiver well-being (CVI=0.85); disruption of family dynamics to Caregiver lifestyle disruption (CVI=0.85); perceived spiritual well-being and anger for Caregiver emotional health (CVI=0.79) and perceived general health to Caregiver physical health (CVI=0.79). Conclusion: the nursing outcomes studied had adequate content validity. It is recommended that content validation followed by clinical and construct validation of the nursing-sensitive outcomes be given in different cultures and care settings.