This paper presents an overview of the fish fauna of Malpelo Island in the Colombian Pacific, highlighting the state of knowledge of the resource and its importance to national and international industrial fisheries . Assessments are reviewed and analyzed based on the retention of more than 20 years in the area, conducting examinations and assessments through scuba diving, fishing and industrial fishing both demersal and pelagic. A total of 147 species and 53 families have been recorded, highlighting the confirmation of 40 newreports for the Colombian Pacific. Recommendations are made on some measures of protection and research of immediate implementation, in order to conserve valuable marine ecosystems found in the Santuario de Flora and Fauna, a heritage and national reserve area since 1995.