Objective: To describe the relationship between the presence of early maladaptive schemas in self-esteem and sexual satisfaction in adults; men and women with heterosexual preference in the Medellin metropolitan area. Sexual satisfaction is a topic of interest in the field of psychology, which in Colombia has been treated by gynecologists and urologists. Early maladaptive schemas are cognitive-affective structures with a high emotional charge which develop during the first years of life as a result of the interaction between baby and caregivers and which later on are directly or indirectly related to psychological disorders. Methodology: Observational, analytical, cross-sectional study. Variables were not deliberately manipulated nor influenced upon. Comparisons were established and the relationships between early maladaptive schemas in self-esteem and the index of sexual satisfaction in young adults in Medellin were analyzed. Results: Of the sample total, 59.3% of the population had one or more active early maladaptive schemas in self-esteem; 60.3% of subjects with active schemas in self-esteem were sexually dissatisfied. Conclusions: Statistical relationships (p  <0.01) with clinical relevance were confirmed amongst early maladaptive schemas in self-esteem and sexual satisfaction. Defectiveness/ unkindness was the schema with highest correlation with the sexual satisfaction index.