Previous studies have shown that physical exercise of resistance and strength are related to cardiovascular health. PURPOSE: This study aims to establish the relationship between maximum oxygen consumption, percentage of muscle mass and cardiovascular risk disease in professors from the Santo Tomas University of Bogota - Colombia. METHODS: The population was 56 men with a mean age of 42.1 ± 9.5 years. The 10-years cardiovascular risk (10y-CVR) was calculated using the Framingham scale, considering the parameters of gender, age, presence of diabetes, smoking (cigarettes per day), total cholesterol (Total-C), HDL cholesterol (HDL-C) and systolic blood pressure (SBP). Pre-prandial blood samples were collected and blood pressure was evaluated after 15 minutes of rest. In a different session, the muscle mass percentage (MP) was evaluated by bioimpedance, a submaximal fitness test (modified Bruce protocol) was performed and the maximum oxygen consumption (VO2max) was calculated based on the test duration. The statistical analysis was performed using the Pearson’s correlation coefficient (r) with a significance level of 0.05. RESULTS: In the evaluated subjects, one was diabetic and 16 men smoke up to 20 cigarettes per day. The Total-C was 5.58 ± 1.09 mmol/l, the HDL-C 1.27 ± 0.24 mmol/l and the SBP 106.7 ± 10.2 mmHg. The 10y-CVR was 5.5 ± 5.2%, with a range of 0.5 - 21.3%. The average of MP was 34.7 ± 3.1% and the relative VO2max 49.1 ± 11.1ml/Kg/min. A negative correlation was observed between the MP and 10y-CVR (r = -0.38 p = 0.01) as well as between VO2max and RCV (r = -0.51 of p <0.01). CONCLUSION: The results of this research evidence the protective effect on the risk of cardiovascular disease arising from a good aerobic capacity, especially by the reduction Total-C, lower SBP and a greater amount of MP. This work contributes to evidence the beneficial effects of combining aerobic and of strength exercise in reducing cardiovascular risk, which will be used in prevention programs within the Santo Tomas University population.