Amitraz poisoning is not frequent in Colombia. The objectives of this case report are to consider the atypical poisoning in an elderly patient and to emphasize the associated toxic-kinetic and toxic-dynamic aspects. The literature mainly consists of case reports and case series in North America. There is a need for the health personnel involved in the treatment of these patients to recognize key aspects of its physiopathology and treatment. The case reported involves a male patient aged 73 with amitraz poisoning, initially without alterations after 33 hours, presenting sensory alterations and respiratory compromise requiring attention in the Special Care Unit (SCU). The patient recovered satisfactorily.