In article number 1600522, a novel label-free microfluidic electrochemical biosensor with a unique built-in on-chip regeneration capability for continual measurement of cell-secreted soluble biomarkers from an organoid culture is reported by Su Ryon Shin, Mehmet R. Dokmeci, Ali Khademhosseini, and co-workers. The biosensor is operated in a fully automated manner without attenuating the sensor sensitivity.