Introduction: Esthesioneuroblastoma is a rare malignant neoplasm arising from neuroendocrine cells of the olfactory epithelium, being located preferably at the uppermost portion of the nasal septum and cribriform lamina. The higher incidence between the second and sixth decades of life, with no gender predominance. The most common symptoms are epistaxis, unilateral nasal obstruction, and anosmia. The treatment includes excision associated with radiotherapy.