Introduction: Cystic fibrosis is one of the most prevalent autosomal recessive diseases in the Caucasian population. It has high morbidity and mortality because of chronic endobronchial infections associated with obstructive pulmonary disease and progressive intestinal malabsorption secondary to pancreatic insufficiency. Approximately, 70 to 100% of patients develop chronic rhinosinusitis and nasal polyposis which is present in 40% of cases.