This experienced work was developed in Tecnoacademia Risaralda in the lab biotechnology, with the practice of the scientific method, and was based on the implementation of learning guides that relate specifically how you can use the scientific method and its steps to generate Experiences science the aim of this work is to run practices in applied science and scheduled programs that interpret by developing projects in the laboratory. The work begins with a reflection of specific topics of biology in which opportunities for research work, followed by the implementation of the steps of the scientific method begins with the observation, they identify this practice opens up new opportunities and different ways of View the world of biology. With the practice of applied biology in learning the principles of generating research, and recognition of the steps proposed by the scientific method to develop clear and precise protocols with the investigator to accept or reject the proposed hypothesis.